新生儿肺炎患儿血中SOD、LPO和VE的测定

CHANGE OF SOD LPO AND VE IN VENOUS BLOOD IN NEWBORN INFANTS WITH PNEUMONIA

本文测定了74例新生儿肺炎患儿血中SOD活性、LPO和VE浓度并与32例足月正常新生儿做比较.结果显示：SOD活性在急性期显著降低，恢复期虽有回升，但仍未达到正常水平。LPO浓度在急性期显著高于恢复期和正常对照组，以重症者更明显。VE浓度在急性期显著1低于正常对照组。34例患儿急性期和恢复期的自身对照结果，三项指标在两期之间均有显著性差异。结果表明自由基脂质过氧化损伤机制参与或加重了肺炎的病理过程。

Blood superoxide dismutase (SOD), lipid peroxidation (LPO) and vitamin E (VE) were determined in 74 newborns with pneumonia and 32 healthy full - term newborns. The results sllowed a reduction of SOD and VF and an eleviltion of LPO in acute stage especially in severe patients compared with the convalesccnt stage and the control group. There has been significant difference in self - control of SOD, LPO and VE compared actue with convalescent stage in 34 cases. It suggests that lipid peroxidation induced by free radicals may be responsible for the pathagenesis of nconatal pneumonia. Free radicals may take part in of aggravation the pathogenic proccss of pneumonia. Determing the SOD activity in RBC and the concentration of LPO as well as VE in serum in the course of neonatal pneumonla may reflect the decease and growth of free radicals of the antioxidative conditions in body, infer degree damaged by lipid peroxidat ion in iungs