新生儿感染时血浆纤维结合蛋白变化的临床意义

THE CLINICAL SIGNIFICANCE OF PLASMA FIBRONECTIN LEVELS IN NEONATES WITH INFECTIOUS DISEASES

本文测定了54例患感染性疾病的新生儿及52名足月健康新生儿血浆纤维结合蛋白（P－FN）含量。新生儿感染极期为160±76μg／ml；新生儿感来恢复期为325±130μg／ml；足月健康新生儿为246±48μg／ml。各组之间相比有高度显著性差异，结果表明新生儿感染极期P-FN含量明显低于足月健康新生儿，感染恢复期P-FN含量逐渐升高并高于足月健康新生儿。提示测定P-FN含量在新生儿感染性疾病中的变化，具有诊断及判断预后的实用价值。

Plasma fibronectin (P - Fn ) levels were measured by One - dimension rocket immunoelectropfioresis method in 54 neonates with infectious diseases and 52 healthy term neontes.The average P- Fn levels were 160± 76μg/ml. 325 ±130μg/ml and 246 ±48μg/ml in acute stage (54 ). convalencent stage (43) of infectious dlseases and healthy term neonates (52) respectively. There were significantly differenct among the three groups of neonates, The average level was significantly less in acute stagc than that In healthy term neonates. that in convalescent stage was higher than that in healthy term neonates, The result indicates that the measure of P -Fn levels has values in dignosis and estimation of prognosis for neonates with infectious diseases