新生儿血培养凝固酶阴性葡萄球菌多重耐药性与抗生素选择

ANTIBIOTICS SELECTION TO THE MULTIPLY ANTIBIOTIC RESISTANT CNS TRAINS FROM NEONATE BLOOD CULTURES

对新生儿血培养中分离到的75株CNS进行14种抗生素体外药敏试验。结果显示：多重耐药菌株高达78．7％，其中对青霉素G耐药率最高（98．7％），其次为苯唑青霉素（85．3％）；头孢菌素类中，以头孢噻吩、头孢羟唑为好，耐药率均为24．0％；氨基糖甙类中，丁胺卡那霉素耐药率最低（24．0％）；CNS对SMZTMP89.3％敏感，而对万古霉素无一耐药。表明：CNS具有很强的耐药性，万古霉素与SMZ－TMP耐药率低，可能适于治疗CNS引起的感染。

The susceptibility of clinical isolated Coagulase Negative Staphylococci(CNS) to 14 antibiotics were determined by K-B agar diffusion method. Results showed that the multiply antibiotic resistant strains were as high as 78. 7%. Penicillin G possessed the most resistant rate to CNS, accounted for 98. 7%, next was oxacillin (85. 3% ). Among cephalosporins,cephalothin and cefamandole showed stronger antibacterial activities against CNS,with their asme resistant rate (24.0%). Among the aminoglycoside antibiotics. resistant rate of amikacin was the lowest(24. 0%). 89. 3% of CNS were senstive to SMZ-TMP and none of CNS was resistant to vancomycin in the study. That denoted that CNS has strong resistant to the common antimicrobial agents. In treatment of CNS infections,patients may be suggested to use vancomycin or SMZ-TMP which possess a good activity agalnst CNS