红霉素对糖尿病性胃排空延迟的作用

Effect of erythromycin on diabetic gastroparesis

我们对１４例糖尿病性胃排空延迟患者给予红霉素静脉注射２００ｍｇ，以后口服０．２５ｇ，每日３次，共７天。采用超声法测定胃液体排空时间。将２０例正常人作为对照，二种途径给药均使平均半排空和全排空时间正常，静脉注射和口服后胃排空恢复正常的患者分别是１００％和７１％。结果提示红霉素具有促进糖尿病患者胃排空的作用，作为胃动素激动剂，可能是新型胃肠道动力药。

To 14 patients with diabetic gastroparesis,erythromycin was given at doses of intravenous 200 mg,followed by oral 0.25g three times a day for 7 days. Gastric liquid emptying time was measured by means of real-time ultrosonography.In comparison with 20 healthy subjects,erythromycin administered either intravenously or orally normalized beth average half and total emptying time.In 100% patients gastric emptying became normal after intravenous administration,and in 71% patients after oral administration. The results show erythromycin has the effect of accelerating gastric emptying in patients with diabetes mellitus. Erythtomycin acting as motilin agonist,may be a new gastrointestinal prokinetic drug.