口腔鳞癌患者免疫功能测定及其临床意义

EVALUATION ON THE IMMUNITY OF THE PATIENTS WITH SQUA-MOUS CELL GARGINOMA IN THE ORAL CAVITY AND IT CLINICL SIGNIFICANCE

本文从分子学水平和细胞学水平，对３０例口腔鳞癌患者，及相应的正常对照者，做血浆ｃＡＭＰ、ｃＧＭＰ含量及外周血Ｔ淋巴细胞亚群测定。血浆ｃＡＭＰ、ｃＧＭＰ含量测定发现，口腔鳞癌患者ｃＡＭＰ明显低于正常对照者（Ｐ＜０．０１），而ｃｏＭＰ和ｃＡＭＰ／ｃＧＭＰ无明显差异（Ｐ＞０．０５），提示口腔鳞癌患者ｃＡＭＰ抑制肿瘤细胞生长的能力低下，与全身其他部位癌症基本一致。Ｔ淋巴细胞亚群测定发现，口腔鳞癌患者与正常人存在明显差异，主要表现为口腔鳞癌患者ＣＤ３↓（Ｐ＜０．０５），ＣＤ８↑（Ｐ＜０．０１），ｃＤ４／ＣＤ８↓（ｐ＜０．０１），提示口腔鳞癌患者细胞免免疫功能紊乱，免疫平衡失调。

This paper reported plasma cAMP, cGMP and peripheral blood T Iymplho-cyte subpopulation value of 30 patients with squamous cell carcinoma of the oral caivty and matched mormal controls by molecular and celluar level. Plasma cAMP and cGMPanalysis indicated that CAMP value of cancer patients was Significantly lower than that of thenormal controls(p<0.01), but there was no difference between two groups on cGMP and cAMP/cGMP(p>0. 05).This showed that patients’ suppressing function against tumor cell was lower and was the same like other kinds of cancer。 Tlymphocyte analysis indicated that there were sigrificant difference between cancer patients and normal controls, that was patients’CD3 lower ( P<0. 05) ,CD8 higher(p<0.01) and CD4/CD8 lower(p<0.01).this showed there were disturbances of ellular immunofunction and immunologic balance in patients with squamous cell arcinoma of the oral cavity。