高原地区肺气肿与α＿1抗胰蛋白酶关系的研究

ALPHA-1-ANTITRYPSIN OF PATIENTS WITH EMPHYSEMA AT ALTITUDE

本文应用火箭免疫电泳法测定了不同海拔地区正常人α＿１抗胰蛋白酶（α＿１ＡＴ）血清水平，平原地区（上海，海拔５米）３２７人，中度高原地区（西宁，海拔２２６０ｍ）１１６人，高原地区（热水，海拔３７００ｍ）８５人。同时还测定了肺气肿病人α＿１ＡＴ血清水平（西宁地区９７例，热水地区３９例）。测定结果显示正常人α＿１ＡＴ血清水平与年龄性别无关，随居住地海拔增高，α＿１ＡＴ血清水平有增高趋势。中度高原地区肺气肿病人α＿１ＡＴ血清水平与正常人无显著差别，高原地区的肺气肿病人α＿１ＡＴ血清水平低于正常人，其机理尚需进一步探讨。

Alpha-1-antitrypsin(α_1AT)deficiency is an autosomal hereditary disorder associated witha major reduction in serum α_1AT levels.Clinically α_1AT deficiency is associated with emphysemain adults and less commonly,liver disease in neonates;In order to make out the relationship be-tween emphysema and α_1AT,we tested α_1AT serum levels of 528 healthy people at various alti-tude(Shanghai:sea level, 327 persons;Xining: 2 260m above sea level, 116 persons and Reshui:3700m above sea level,85 persons)and 136 patients with chronic pulmonary emphtsema(Xining97 and Reshui 39) with immunoelectrophoresis The results indicated that α_1AT serum levels ofhealthy people were irrelative to sex and age. With the increase of altitude,however α_1AT serumlevels showed a tendency of increase in healthy people. Between patients with emphysema andhealthy people,there was on significant difference in α_1AT serum levels in Xining. However,pa-tients with emphysema,in Reshui,had significantly lower α_1AT serum levels than that of healthypeople. The mechanism need to be further investigated.