不同海拔地区健康人血清α＿1－抗胰蛋白酶水平的比较分析

SERUM α-1-ANTITRYPSIN LEVEL IN HEALTHY RESIDENT AT THE DIFFERENT ALTITUDE

本文应用火箭免疫电泳法分别测定了不同海拔地区总共５７３例健康人血清α＿１－ＡＴ水平，其中上海（海拔５ｍ）３５９人，西宁（海拔２２６０ｍ）１２９人，青海热水（海拔３７００ｍ）８５人。结果为：上海地区健康人血清α＿１—ＡＴ水平２．８１±０．６８ｇ／Ｌ，西宁３．９１±１．１１ｇ／Ｌ，热水３．３６±０．８２ｇ／Ｌ。结果表明，健康人血清α＿１－ＡＴ水平由高到低依次是西宁、热水、上海。经统计学分析三组之间差别有高度显著性意义（Ｐ＜０．０１），而与性别无关（Ｐ＞０．０５）、提示健康人随居住地海拔增高血清α＿１－ＡＴ水平有增高趋势。这种改变可能与海拔增高，空气中氧分压下降刺激肝细胞和肺泡巨噬细胞合成α＿１－ＡＴ增加有关，但随着海拔进一步增高，这种作用反而受到抑制。

e tested α-1-AT serum levels of 573 healthy people at various altitude (Shanghai :sealevel,359 persons;Xining:2 260m above sea level,129 persons and Reshui:3 700m above sea lev-el,85 persons)With immunoelectrophoresis. The results indicated that α _1-AT serum levels ofhealthy people were =2. 81±0.68g/L in shanghai, =3.91±1.11g/L in Xining,=3.36±0. 82g/L in Resui,However,irrelative to sex and age, with the increase of altitude,α_1-ATserum levels showed a tendency of increase in healthy people. The mechanism need to be furthetinvestigated.