复方甲地孕酮和避孕片对大鼠小肠运动的影响

Effect of Compound Megestrol Acetate and Estradiol Injectables and Oral Contraceptive on the Movement of Small Intestinal in Rats.

为了探讨避孕药引起消化道反应的机制,我们观察了避孕片和复方甲地孕酮对去卵巢大鼠小肠移行性综合肌电(MMC)的影响。实验用雌性、成年大鼠(Wistar)20只,随机分为避孕片组和复方甲地孕酮组。卵巢切除后第八天,按照Weisbrodt的方法用多道生理记录仪描记MMC。实验发现:①与对照描记相比,口服避孕药0号使MMC表现为Ⅰ相缩短,Ⅱ相延长,十二脂肠近段(D_2)和空肠周期明显延长(D_2延长44.2％,J延长40.2％,P<0.05)。②与对照描记相比,复方甲 地孕酮使十二指肠始段(D_1)和D_2Ⅱ相、Ⅲ相延长,周期延长(D_1延长68.9％,D_2延长72.8％,P<0.05)。结果提示,甾体类避孕药可扰乱正常小肠电活动,这可能是其引起消化道反应的原因之一。

To study the mechanism of contraceptiveon the reaction of digestive tract,we observed the effect of oral contraceptive and injectiomegestroliet estradioli on small intestinal mi-grating myoelectric complex (MMC) inovariectomied rats. Twenty adult female rats (Wistar) weredivided into two groups:oral contraceptive andinjectio megestroliet estradioli. Seven days af-ter ovariecomy, MMC was recorded by poly-graph system according to Weisbrodt'smethod. The results showed: (1) In compari-son with the control,oral contraceptive short-ened the phase Ⅰ,prolonged the phase Ⅱ andthe cycle of MMC in duodeni inferior (D_2)andjejunal (J)significantly (Prolonged 44.2% and40.2%,P<0. 05). (2)In comparison with con-trol, injectio megestroliet estradioli prolongedthe phase Ⅱ and Ⅲ in duodeni superior (D_1)and D_2and prolonged the cycle of MMC in D_1and D_2(prolonged 68.9% and 72.8%,P<0. 05). It is indicated that contraceptive disturbsthe electrical activity of intestinal.