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POSTMORTEM REDISTRIBUTION KINETICS OF ACONITINE IN RABBITS 被引量:2

POSTMORTEM REDISTRIBUTION KINETICS OF ACONITINE IN RABBITS
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摘要 The postmortem redistribution of aconitine(AC) and its influencing factors by orally ingested Aconitum brachypodum Diels (AbD) in rabbits were studied. The results showed that postmortem AC redistribution did exist, and the diffusion along a concentration gradient was the major influencing factor on it. Change of temperature and incomplete distribution in life also influenced it.Besides those mentioned above, there were other influencing factors. These may be related to postmortem blood movement and toxin released from cells occurring as part of the processes of autolysis and putrefaction. The postmortem redistribution of aconitine(AC) and its influencing factors by orally ingested Aconitum brachypodum Diels (AbD) in rabbits were studied. The results showed that postmortem AC redistribution did exist, and the diffusion along a concentration gradient was the major influencing factor on it. Change of temperature and incomplete distribution in life also influenced it.Besides those mentioned above, there were other influencing factors. These may be related to postmortem blood movement and toxin released from cells occurring as part of the processes of autolysis and putrefaction.
作者 徐威 胡炳蔚
出处 《Journal of Pharmaceutical Analysis》 CAS 1994年第1期41-46,51,共7页 药物分析学报(英文版)
关键词 postmortem redistribution ACONITINE A-V concentration difference degradation Kinetics postmortem redistribution aconitine A-V concentration difference degradation Kinetics
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