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磁共振成像与活体波谱在阿尔茨海默病实验及临床研究中的应用 被引量：2

Magnetic resonance imaging and in vivo magnetic resonance spectroscopy in studying clinical and experimental Alzheimer disease
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摘要 痴呆是当前世界上的流行病之一 ,阿尔茨海默病是最常见的痴呆类型 ,其诊断和治疗目前都还非常困难。磁共振成像 (MRI)和活体磁共振波谱 (MRS)技术相对于其他诊断和研究手段而言 ,具有其特有的无损伤性和多功能性。随着近年来磁共振成像仪在全世界范围内的广泛普及 ,磁共振技术在阿尔茨海默病的临床诊断和实验研究中应用发展迅速并日趋广泛。本文综述了磁共振成像和活体磁共振波谱技术近几年来的最新进展及其在阿尔茨海默病研究中的应用 ,还简述了磁共振在阿尔茨海默病动物模型中的研究。 Having the combined advantages of noninvasiveness, versatility and wide-availability, magnetic resonance imaging (MRI) and in vivo magnetic resonance spectroscopy (MRS) nowadays are widely used in clinical diagnosis and experimental investigations of Alzheimer disease. This paper reviews some recent technological developments of magnetic resonance and their applications in studying Alzheimer disease.
作者 杜小霞 雷皓
机构地区 中国科学院武汉物理与数学研究所
出处 《中国医学影像技术》 CSCD 2004年第6期957-961,共5页 Chinese Journal of Medical Imaging Technology
基金 国家自然科学基金项目(1 0 2 340 70 )和 (30 370 4 1 9)资助
关键词 磁共振成像 磁共振波谱 痴呆 阿尔茨海默病 Magnetic resonance imaging Magnetic resonance spectroscopy Dementia Alzheimer disease
分类号 R749.16 [医药卫生—神经病学与精神病学] R445.2 [医药卫生—影像医学与核医学]
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参考文献43

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同被引文献27

  • 1丁新生.老年性痴呆的病理、发病机制及其诊断研究[J].中国临床康复,2004,8(19):3885-3887. 被引量：25
  • 2杨期东,周琳.中国阿尔茨海默病的流行病学特征[J].中国临床康复,2004,8(31):6982-6983. 被引量：19
  • 3谭纪萍,张晓红,王鲁宁.阿尔茨海默病的流行病学研究概况[J].中华预防医学杂志,2005,39(2):146-148. 被引量：13
  • 4陈静,胡晓晴.认知事件相关电位在阿尔茨海默病中的临床作用[J].国外医学（物理医学与康复学分册）,2005,25(2):77-79. 被引量：1
  • 5郭明丽,杨伟炎,王秋菊.失匹配负波简介及其听力学应用前景[J].听力学及言语疾病杂志,2006,14(2):141-143. 被引量：13
  • 6Mosconi L, Pupi A, De Cristofaro MT, et al. Functional interactions of the entorhinal cortex: an ^18F-FDG PET study on normal aging and Alzheimer's disease[J].J Nucl Med,2004,45(3):382-392.
  • 7Imabayashi E, Matsuda H, Asada T, et al. Superiority of 3-dimensional stereotactic surface projection analysis over visual inspection in discrimination of patients with very early Alzheimer's disease from controls using brain perfusion SPECT[J].J Nucl Med,2004,45(9):1450-1457.
  • 8Silverman DH. Brain ^18F-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging[J].J Nucl Med,2004,45(4):594-607.
  • 9Honda N, Machida K, Matsumoto T, et al. Three-dimensional stereotactic surface projection of brain perfusion SPECT improves diagnosis of Alzheimer's disease[J].Ann Nucl Med,2003,17(8):641-648.
  • 10Silverman DH, Gambhir SS, Huang HW, et al. Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits[J].J Nucl Med,2002,43(2):253-266.

引证文献2

二级引证文献6

中国医学影像技术
2004年 第6期

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