硝氯酚吡喹酮治疗家犬卫氏并殖吸虫病的疗效观察

AN OBSERVATION ON THE THERAPEUTIC EFFECT OF NICLOFOLAN AND PRAZIQUANTEL IN THE TREATMENT OF CANINE PARAGONIMIASIS WESTERMANl

本文对硝氯酚、吡喹酮治疗家犬卫氏并殖吸虫病进行了疗效观察.实验设两个治疗组(每组4犬),一组给硝氯酚 2mg/kg顿服,一组给吡喹酮 50mg/kg/d×2d治疗,另5犬不给药作为对照.于治后3—4个月剖杀,病理切片镜检见治疗组家犬肺部病变多为纤维化结节及部份恢复正常的肺组织结构.对照组平均每犬检获成虫39.6±6.7条,硝氯酚组为5.8±1.2条、减虫率85.4%、4犬中有1犬呕吐、双目失明.吡喹酮组为14±7.0条、减虫率64. 6%、无明显毒副反应.作者认为硝氯酚对卫氏并殖吸虫有较强的杀伤作用,但毒性较大、副反应重;吡喹酮的疗效偏低,可能与剂量不足、以致杀虫作用不够完全有关.

This paper demonstrated the therapeutic effect of niclofolan and praziquntel in treatment of canine Paragonimiasis westermani. 4 dogs were treated with a single dose of 2mg/kg niclofolan,another 4 dogs with praziquantel 50mg/kg/d×2,and 5 dogs were used as control?The animals were dissected 3- 4 months after treatment for pathological examination.The main pathological changs under microscope were formation of fibrous nodules and the lung tissue was partially recovered. The average number of adult worm which were discovered from the control group was 39. 6±6.7/dog and 5. 8±1.2/dog for the niclofolan group,with a reduction rate of 85. 4% ,but one out of 4 treated dogs in this group had vomiting and developed blindness. For the praziquantel group, the average number of adult worms discovered was 14±7.0/dog with a reduction rate of 64. 6% ,and no obvious toxic or side effect was observed. The authors concluded that niclofolan had strong killing effect on canine paragonimiasis but with a high toxicity. The effect of praziquantel was weak,but it could be due to the insufficient dosage of the drug.