日本血吸虫感染后IgG和IgM抗体反应动态观察

DYNAMIC OBVERSATION ON IGG AND IGM ANTIBODIES AFTER INFECTION OF SCHISTOSOMA JAPONICUM

本文用5种日本血吸虫抗原动态观察了实验感染小鼠血清特异性IgG和IgM抗体反应,并检测了慢性血吸虫病患者血清IgG和IgM抗体。结果显示,感染小鼠的IgG反应对SEA、JEU和JWU3种抗原的反应最强,感染后第6wk急剧上升,第7wk达到高峰,并持续在较高水平至观察结束的第16wk;小鼠的IgM抗体反应以对SEA和JEU两种虫卵抗原的反应最强,第4wk后显著上升,第7—8wk达到高峰。以后逐渐下降。检测125例慢性血吸虫病患者血清,IgG抗体阳性率以SEA、JEU、JWU为最高(88.8％—95.2％),IgM抗体阳性率以SEA最高(65.6％)。上述结果可为免疫诊断、血清流行病学调查及考核防治效果提供科学参考资料。

The specific IgG and IgM antibodies in innocalated mice and patients with chronic schis-tosomiasis were studied by using 5 kinds of schistosoma antigens. The results showed that in the mice the responses of IgG antibody to SEA,JEU and JWU were higher, which rised sharply at the 6th week after infection,reached the peak at the 7th week and maintained high peak up to the 16th week. The responses of IgM to two egg antigens,SEA and JEU.were higher than the others,which increased at the 4th week and reached the peak at 7th or 8th week and then decreased gradually afterward. With sera of 125 patients with schistosomiasis japonica,3 kinds of antigens, SEA ,JEU and JWU,gave rise to higher positive rates of specific IgG:95. 2%,92. 0% and 88. 8% respectively. 65. 6% was the highest positive rate of specific IgM against SEA. The results might provide the scientific basis for the immunodiagnosis, seroepidemiology and assessment of the efficiency of control of schistosomiasis.