儿童脑膜炎脑脊液中前列腺素的变化

The change of prostaglandin contents in cerebrospinal fluid of children with meningitis

本文对24例脑膜炎患儿包括结核性脑膜炎(结脑)、化脓性脑膜炎(化脑)、病毒性脑膜炎(病脑)和9例非中枢神经系统感染儿童脑脊液(CSF)中前列腺素(PG_s)包括PGF_(2α)PGF_2、6—酮—PGF_(1α)含量进行了测定。结果表明,脑膜炎患儿CSF中PG_s三项指标皆较对照组显著升高,其中以结脑组最高,PGF_(2α)在三项指标中升高尤为明显,表明PG_s在脑膜炎炎症反应及组织损伤过程中生成增多并释放至CSF中。

The study was carried out for the prostaglandins of cerebrospinal fluicl(CSF) in 24 cases for children with tuberculous and purulent and virus meningitis,and 9 cases for children with non—central nerve system infection. The results showed that the contents of prostaglandins (PGF_(2α),PGF_2, 6—Keto—PGF_(1α)) were remarkably enhanced in the patients,especially tuberculous meningitis, PGF_(2α) was the highest among the PGS of CSF. We thought,probably ,products of PGS were increased in the course of inflammatary reaction and injured tissue and released into CSF.