STUDIES ON THE SYNTHESIS OF DIMETHYI,4-HYDROXY -4'-METHOXY-5,6,5',6'-BISMETHYLENEDIOXYBIPHENYL-2,2'-DICAPBOXYLATE——AN ESSENTIAL METABOLITE OF DDB

STUDIES ON THE SYNTHESIS OF DIMETHYI,4-HYDROXY -4'-METHOXY-5,6,5',6'-BISMETHYLENEDIOXYBIPHENYL-2,2'-DICAPBOXYLATE——AN ESSENTIAL METABOLITE OF DDB

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摘要 This paper reports the total synthesis of dimethyl 4-hydroxy-4’-methoxy-5,6,5’,6’-bismethylenedioxybiphenyl-2,2’-dicarboxylate(Ⅱ). Various conditions for bromination were tried to find the best one for synthesis of the key intermediate compd 6.After Lllmann condensation of 6 with 8 and hydrogenolysis, the title compd Ⅱ was obtained.It was proved to be identical with the isolated metabolite of DDB by spectral data. This paper reports the total synthesis of dimethyl 4-hydroxy-4’-methoxy-5,6,5’,6’-bismethylenedioxybiphenyl-2,2’-dicarboxylate(Ⅱ). Various conditions for bromination were tried to find the best one for synthesis of the key intermediate compd 6.After Lllmann condensation of 6 with 8 and hydrogenolysis, the title compd Ⅱ was obtained.It was proved to be identical with the isolated metabolite of DDB by spectral data.

作者 Shu Li ZHAN Chun Zhen ZHANG Institute of Materia Medica,Chinese Academy of Medical Sciences Beijing 100050

出处《Chinese Chemical Letters》 SCIE CAS CSCD 1992年第1期29-32,共4页 中国化学快报（英文版）

关键词 AN ESSENTIAL METABOLITE OF DDB BISMETHYLENEDIOXYBIPHENYL-2 2 DICAPBOXYLATE METHOXY-5 6 5 STUDIES ON THE SYNTHESIS OF DIMETHYI 4-HYDROXY

分类号 O6 [理学—化学]

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Chinese Chemical Letters

1992年第1期

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STUDIES ON THE SYNTHESIS OF DIMETHYI,4-HYDROXY -4'-METHOXY-5,6,5',6'-BISMETHYLENEDIOXYBIPHENYL-2,2'-DICAPBOXYLATE——AN ESSENTIAL METABOLITE OF DDB

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