肝硬化患者血浆心钠素与醛固酮及血清蛋白含量的观察

The Investigation of Plasma ANP ALD and Serum Protein in Patients with Decompensation Cirrhosis

本文报告65例失代偿期肝硬化(其中合并腹水者44例,无腹水者21例)血浆心钠素(ANP)、醛固酮(ALD)和血清蛋白(A/G)的结果,并与12例正常人进行了对比。肝硬化组ANP与ALD含量明显高于正常组(P<0.01)。肝硬化合并腹水组ANP和ALD含量明显高于无腹水组(P<0.01),而血清白蛋白含量两组之间无显著差异(P>0.05)。结果提示肝硬化患者腹水形成与体内ANP和ALD升高的因素有关,单纯低白蛋白血症不足以产生腹水,故治疗肝硬化腹水时,应采用综合治疗法。

Plasma atrial natriuretic peptide(ANP) aldosterone(ALD)and serum protein level of 65 patients with decompensation cirrhosis(of them there were 44 cases with ascites and 21 casea without ascites)were reported by this paper, and compared with 12 cases of normal subjects. It was shown that the results of ANP and ALD of decompensation cirrhosis patients were much higher than that of normal group(P<0.01),and patients with ascites were much more higher than that without ascites(P<0.01). Serum albumin level of the ascites group were lower than that of normal group(P<0.05),between the two groups with ascites and without ascites there was no discrepancy at the(P>0.05) level. It was suggested that formation of ascites with decompensation cirrhosis is related to higher level of ANP and ALD, and that simple low serum albumin is not enongh to induce ascites. so it is not enongh to treat the patients simply with complement of albumin in ascites of decompensation cirrhosis.