摘要
One hundred and sixty-eight specimens of intestinal metaplasia(IM)with variousaccompanying lesions in gastric mucosa were studied with mucohistochemical and ABCimmunohistochemical staining,The quantitative analysis of cell DNA was done withflowcytometry for 36 specimens.The results indicated that the incidence of type Ⅱb IM wassignificantly higher in the groups of dysplasia(34.6％)and mucosa adjacent to gastric cancer(GC)(51.7％)than in the chronic atrophic gastritis(CAG)group(16.0％)(P【0.01).The expres-sion rate of monoclonal antibody MG7 related antigen(MG7-Ag)in type Ⅱb IM(473％)wasalso significantly higher than those in type la(29.7％),Ib(26.1％)and Ⅱa IM(28.3％)(P【0.05).Expression rate of MG7-Ag,DNA aneuploid rate and percentage of S phase cell werestatistically higher in the type Ⅱb IM with dysphsia(62.5％,62.5％ and 143±32)than in typeⅡb 1M without dysplasia(47.3％,12.5％and12.7±2.9)(P【0.05 and P【0.01).These findingssuppor the supposed progressive process:CAG→type Ⅱb IM→dysplasia→GC,andtype Ⅱb IM with dysplasia is closely associated with GC.
One hundred and sixty-eight specimens of intestinal metaplasia(IM)with various accompanying lesions in gastric mucosa were studied with mucohistochemical and ABC immunohistochemical staining,The quantitative analysis of cell DNA was done with flowcytometry for 36 specimens.The results indicated that the incidence of type Ⅱb IM was significantly higher in the groups of dysplasia(34.6％)and mucosa adjacent to gastric cancer (GC)(51.7％)than in the chronic atrophic gastritis(CAG)group(16.0％)(P<0.01).The expres- sion rate of monoclonal antibody MG7 related antigen(MG7-Ag)in type Ⅱb IM(473％)was also significantly higher than those in type la(29.7％),Ib(26.1％)and Ⅱa IM(28.3％)(P< 0.05).Expression rate of MG7-Ag,DNA aneuploid rate and percentage of S phase cell were statistically higher in the type Ⅱb IM with dysphsia(62.5％,62.5％ and 143±32)than in type Ⅱb 1M without dysplasia(47.3％,12.5％and12.7±2.9)(P<0.05 and P<0.01).These findings suppor the supposed progressive process:CAG→type Ⅱb IM→dysplasia→GC,and type Ⅱb IM with dysplasia is closely associated with GC.
