摘要
In this study,the changes in activity and mRNA transcript of basic fibroblast growth fac-tor(bFGF)in lung injury and the effect of prostacyclin on the treatment of lung injury wereinvestigated.The result of the experiment revealed that there were not any bioactive bFGF andbFGF mRNA in the lung tissue of normal dogs.bFGF activity and bFGF mRNA were detectedonly in the injured lung tissue.Prostacyclin could slightly elevate the activity of bFGF andsignificantly elevate the level of bFGF mRNA.The findings suggest that(1)the level of bFGF in-creased after lung injury.(2)Prostacyclin could influence the expression of bFGF.(3)bFGF couldplay an important role in the repair of injury lung tissue.
In this study,the changes in activity and mRNA transcript of basic fibroblast growth fac- tor(bFGF)in lung injury and the effect of prostacyclin on the treatment of lung injury were investigated.The result of the experiment revealed that there were not any bioactive bFGF and bFGF mRNA in the lung tissue of normal dogs.bFGF activity and bFGF mRNA were detected only in the injured lung tissue.Prostacyclin could slightly elevate the activity of bFGF and significantly elevate the level of bFGF mRNA.The findings suggest that(1)the level of bFGF in- creased after lung injury.(2)Prostacyclin could influence the expression of bFGF.(3)bFGF could play an important role in the repair of injury lung tissue.
