非酒精性脂肪肝肝纤维化指标与中医辨证分型相关性探讨

Correlation between Nonalcoholic Steato Hepatitis and Symptom Types of Chinese Medicine

目的探讨非酒精性脂肪肝患者肝纤维化指标与中医辨证分型的关系。方法将46例非酒精性脂肪肝患者予以中医辨证分型,并作肝纤维化指标检测,以不嗜酒的健康人作为对照。结果脂肪肝组肝纤维化指标明显高于对照组(P<0.05,P<0.01);治疗组内各证型间比较,痰浊夹瘀型的Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)明显高于其他三型。结论非酒精性脂肪肝患者存在不同程度的肝纤维化倾向,并与中医辨证分型具有一定的关系。

Objective To discuss the relationship between hepatic fibrosis index (HFI) of nonalcoholic steato hepatitis (NASH) patient and symptom types of Chinese Medicine (CM). Method There were 46 cases of NASH accorded with the diagnosis standard of adiposis hepatica (AH). The patients, as group 1, were divided into different types according to the principles of CM and given the test of HFI. The healthy people being not addicted to drink were taken as group 2. Result The HFI of group 1 was higher than that of group 2 obviously (P<0.05, P<0.01). Among the different symptom types in group 1 the type of phlegm mixed with blood stasis had higher level of procollagen Ⅲ (PCⅢ) and laminin (LN) than other three types. Hyaluronic acid (HA) and collagen Ⅳ (CⅣ) had no significant difference among different types (P<0.05). Conclusion The patient with NASH has a tendency of hepatic fibrosis and there is a relationship between the patient of NASH and symptom types of CM.