可吸收性甲硝哒唑药膜的研究

A Study on Resorbable Local Metronidazol Delivery Devices

利用可溶性羟丙基甲基纤维素(HPMC)研制出一种可吸收性甲硝哒唑(MTZ)药膜,观察其抑菌作用及临床疗效。结果表明:离体条件下24小时内HPMC缓慢溶解,MTZ几乎完全释放,活体牙周龈沟液中24小时后MTZ的量仍维持40μg/ml的水平(远高于牙周病相关菌的最低抑菌浓度),HPMC逐渐溶解消失。

A local metronidazol (MTZ) delivery using resorbable base material was studied. In vitro MTZ was almost completely released within 24 hrs from the hydrox-ypropylmethyl cellullouse (HPMC) strips. In vivo, release of the drug from strips was also measured in six patients who had deep pockets of more than 5mm. MTZ -containing HPMC strip was inserted in the pocket. The average amount of MTZ in the gingival crevicalar fluid (GCF) 24 hrs after insertion of strip was 40μg/ml. (much higher than the reported MIC of some microorganisms associated with adult periodontitis). In vitro there were significant inhibitory effects of MTZ containing strips on the microorganisms associated with periodontal disease. The prevalence of spirochetes and motil rods, and gingival index (GI) was remarkably reduced in the MTZ administered pockets, It is suggest that this new direct drug delivery system with HPMC used as base material could be used to treat periodontal disease.