离子导入复方灯盏花加速兔牙移动的实验研究

The effect of EBCI Iontophoresis on orthodontic tooth movement in rab- bits

为考察复方灯盏花(EBC)离子导入对兔牙移动速度的影响,本实验选择年轻家兔21只,随机分三组,分别在兔下颌切牙牙龈处进行EBC离子导入、生理盐水导入及局部注射。动物下颌切牙均装置统一规格矫正器。结果显示第14天时EBC导入组牙移动距离为4.2754±0.1214(mm);生理盐水导入组及注射组分别为3.337土0.4626(mm)及2.1784±0.2922(mm),有统计学意义。光镜显示EBC导入组牙周压力侧破骨细胞数目多,牙槽硬骨板吸收明显,张力侧有明显新骨堆积,生理盐水导入及注射组缺乏典型的吸收及修复相,表明EBC离子导入在促进兔牙周改建及加速兔牙移动方面发挥了积极作用。

The purpose of this study was to ob- serve the effect of EBC iontophoresis on increasing the rate of tooth movement in rabbits. 21 rabbits, in whose lower incisors the standard orthodontic appliances were placed, were divided into 3 groups at random which separately received iontophoresis of EBC, iontophe esis and injection of physiological saline at the sub-mucosal area of the lower incisors. The results showed that the animals with EBC iontophoresis obtained tooth movement rate of 4. 275 ±0. 1214 (mm) and the animals with NaCl iontophoresis and injection were respectively 3. 337 ± 0. 4626 (mm) and 2. 178±0. 2922 (mm). The histologi-cal observation had also found the evidence of the ability of EBC to stimulate osteo-clasts in preiodontal pression side and os-teoblasts in tension. This study suggested that iontophoresis of EBC could play an important role in reconstructing the peri-odontum and speeding the tooth movement in rabbits.