眼部横纹肌肉瘤30例的临床病理和免疫组织化学研究

Retrospective study of the diagnosis, treatment, pathology and histochemistry of 30 cases of ocular rhabdomyosarcoma (RMS)

回顾30例眼部横纹肌肉瘤的临床资料,就其临床诊断、治疗、病理和免疫组织化学等问题进行了探讨。本肿瘤多见于儿童和青少年,病程较短,生长迅速,多居眼眶鼻侧。一经病理诊断证实为本肿瘤,应立即施行放射疗法或/和化学疗法。特别指出:本病病理诊断困难,以能辨识肌细胞的肌红蛋白、结蛋白或波蛋白作为标记物,进行免疫组织化学染色,是确诊本病的有效手段。

Retrospective study of the diagnosis, treatment, pathology and histochemistry of 30 cases of ocular rhabdomyosarcoma(RMS). Sun Xianli et al. Beijing Institute of Ophthalmology, Beijing100730 The RMS occurs commonly in children and adolescents in the upper lid and nasal quadrants ofthe orbit. Radiation therapy alone or in combination with chemotherapy can be successfully employed to combat this extremely rapid growing tumor. Pathologic diagnosis is very difficult, especialy for the undifferentiated type. Myoglobin, desmin and vimentin are specific markersfor the detection of muscle cells. The authors used immunohistochemical stain and found that these immunomarkers were effective means for the diagnosis of RMS.