正常人和闭角型青光眼房水环一磷腺苷酸的测定

Radioimmunoassay of cAMP in aqueous humor of normal human and angle-closure glaucoma patients

为研究人眼环一磷腺苷酸(cAMP)在房水动力过程中的调节作用,应用放射免疫技术,测定了50例正常人和29例闭角型青光眼的房水cAMP含量。正常人眼房水cAMP含量为13.53±5.81pmol/ml,房水含量与年龄成正相关;急性闭角型青光眼发作期cAMP含量与眼压水平正相关,缓解期房水cAMP含量低于正常眼和发作期;慢性闭角型青光眼房水cAMP含量与眼压水平无显著相关性,但明显低于正常眼。对闭角型青光眼的发病机理也进行了讨论。

Radioimmunoassay of cAMP in aqueous humor of norreal human and angle—closure glaucoma patients. Yao Xiao-ming et al. Department of Ophthalmology, Shandong Provincial Hospital, Jinan 250021 The contents of cAMP in aqueous humor of 50 normal human eyes, 11 eyes of acute angle-closure glaucoma(AACG) and of 18 eyes of chronic narrow angle glaucoma(CNAG) were determined with radioimmunoassay. The results were that in the normal eyes, the mean level of cAMP was 13.53±5.8 pmol/ml and negatively correlated with age. The level of cAMP in AACG during an acute attack was positively correlated with the intraocular pressure, whereas during remission, the level of cAMP was lower than the normal. The pathogenesis of angle-closure glaucoma was discussed.