射频消融冠状窦的实验研究

Catheter Ablation in Canine Coronary Sinus Using Radiofrequency Energy

对16条犬进行射频导管消融冠状静脉窦的作用及安全性研究.射频于冠状窦内电极导管和胸部片状电极间释放,能量为1229±711焦耳.13条犬于消融后半小时处死,3条犬于3～4周后处死.消融部位损伤长3.2±1.8mm,宽2.2±1.7mm,深2.±1.0mm,镜下所见为边界清晰的凝固性坏死(急性期)与纤维化(慢性期).冠状动脉、二尖瓣及心内膜均未受累.除二条犬偶发房性早搏或室性早搏外无心律失常发生,无血流动力学改变,无1例发生冠状静脉窦破裂.表明高能射频消融冠状静脉窦安全,就其损伤部位而论可能对破坏病人的左侧房室旁道有效.

The safety and effectiveness of catheter ablation in coronary sinus using radiofre-quency energy was studied in 16 dogs. Radiofrequency energy(1229±711 J) was applied between electrode catheter placed inside coronary sinus and a chest wall patch. Thirteen dogs were killed approximately half an hour after ablation and three 3 to 4 weeks. Lesion of abltion area were 3. 2±1. 8mm in length, 2. 2±1. 7mm in width and 2. 1±1. 0mm in depth. Microscopic examination showed well circumscribed area of coagultion necrosis (acute period)and fibrosis (chronic period). The coronary atery and mitral apparatus were not involved,nor was the endocadium. No arrhyth-mias except occationally atrial or ventricular premature beats were observed. No hemodynamic changes and rupture of coronary sinus occurred in any dog. Large amount of radiofrequency energy can be safely applied to the coronary sinus. The location of the lesions produced suggests that this technique may be useful for interruption of left-sided atioventricular pathways of patients.