非清创涂布MEBO早期处理烧伤创面的实验研究

EXPERIMENTAL RESEARCH ON THE APPLICATION OF MEBO AT THE EARLY STAGE OF BURN WITHOUT DEBRIEDEMENT

作者应用人工烧伤家兔后涂布金黄色葡萄球菌。一对组在不清创的基础上分别应用MEBO及凡士林作为外用药;另一对组创面应用传统清创方法后,分别涂布MEBO或凡士林作比较。两对组在三日后进行细菌培养。结果阳性率第一对组为6.67％及100％;清创组分别为0及30％。两对组比较差别非常显著P<0.01。两对组应用MEBO之阳性率比较差别不显著P>0.05。作者认为不清创即涂药(MEBO)是可行的。作者对其机理进行了探讨。

Rabbits were artificially burned and smeared with Staphylococcus aureus. The two pairs of rabbits were divided into two groups. Animals in the 1st group were treated with MEBO and vaseline respectively without debriedement. Animals in the second group were treated with MEBO and vaseline respectively after debriedement. 3 days later, bacterial cultures were performed. In the 1st group, the positive rates were 6. 67% and 100% and in the second group, the positive rates were 0% and 30%. The difference between the two groups was very significant P<0. 01, But the difference between the animals treated with MEBO in the two groups was of no significance P>0. 05. The authors concluded that MEBO can be applied to the wounds without debriedement. The mechanism of action was discussed.