摘要
自1978年以来,我们在液体扩容防治烧伤休克的基础上,加用了山莨菪碱治疗。通过对99例临床病例治疗,并同单纯液体扩容组(68例)进行了比较,证明山莨菪碱在输液总量不增加的情况下,尿量明显增加。动物实验研究表明,该类药物能增加烧伤家兔有效肾血浆流量,改善烧伤后血液流变学与血流动力学,减轻烧伤组织含水量,解除烧伤周围区域皮肤小动脉痉挛等作用。作者认为,在液体扩容的基础上,山莨菪碱能通过多种渠道改善烧伤早期的微循环功能,从而保障了微循环单位的良好灌流,中断或减轻组织细胞缺血、缺氧,及最终并发的弥散性血管内凝血这一恶性循环。
Anisodamine is a new kind of anticholine drugs mainly developed by Pharmaceutical Re-search Institute, Chinese Academy of Medical Science in April. 1965. 654-2 is its tradename.
We have combined anisodamine with fluid resuscitation therapy in the prevention treatment of burn shock since 1978.
We treated 99 cases with the above-men-tioned therapy and comfirmed that patient's urine
output increased considerably after application of anisodamine on condition that total intravenous volumes remained at the same level. This result was compared with 68 cases treated with fluid re-suscitation thearpy only.
Experimental studies on burn rabbits showed that anisodamine can increase effective renal plasma flow, improve blood rheology and blood flow dynamics, reduce water content of burn rissues and remove convulsions of arteriolae tion therapy. It assures adequate blood flow of
around burn wound areas. microcirculation units, removes or relieves
The writer is convinced that anisodamine im- ischaemia and anoxia of tissue cells, and eventual-
proves microcirculation at the early stage of burn ly prevents the vicious circle-disseminated
hrough many ways on the basis of fluid resuscita- intravascular coagulation.
出处
《中国烧伤创疡杂志》
1992年第1期23-28,22-66,共9页
The Chinese Journal of Burns Wounds & Surface Ulcers
