特异性环氧化酶Ⅱ抑制剂联合前列回春胶囊治疗慢性盆腔疼痛综合征的研究

Study of cyclooxygenase-2 inhibitor combined with Qianliehuichun capsule on chronic pelvic pain syndrome

目的 从治疗学的角度探讨慢性盆腔疼痛综合征的可能病因及治疗选择。方法将 132例门诊诊断为慢性盆腔疼痛综合征的患者在平均年龄、病程及慢性前列腺炎症状评分无统计学意义的基础上分为 3组 :A组患者口服塞来昔布 ,B组患者口服前列回春胶囊 ,C组患者同时服用上述 2种药物 ,治疗随访 6周 ,比较治疗前后 3组患者慢性前列腺炎症状评分及前列腺液中卵磷脂小体数量的变化。结果 每组患者治疗前后的症状评分和前列腺液中卵磷脂小体数量的变化均有统计学意义 ;C组分别同A组、B组比较 ,治疗后上述各项指标均有统计学意义。结论 炎症反应能导致慢性盆腔疼痛综合征 ;特异性环氧化酶Ⅱ抑制剂及前列回春胶囊对慢性盆腔疼痛综合征均有一定疗效 ;

Objective It is to discuss the possible pathogeny and treatment choice of chronic pelvic pain syndrome (CPPS) from the direction of therapeutics.Methods 132 outpatients in which there was not statistically difference in average age, illness period and chronic prostatitis symptom index (CPSI) were divided into three groups. The group A was took celecoxib orally, the group B was took Qianliehuichun capsule orally and the group C was took celecoxib combined with Qianliehuichun capsule orally. The treatment period was 6 weeks. The changes of CPSI and ovoid body amount in prostate succus were compared before and after treatment among the three groups.Results The changes of CPSI and ovoid body amount in prostate succus after treatment had statistically differences in the three groups and in group C versus group A or B.Conclusion Inflammation reaction can induce CPPS. Both cyclooxygenase-2 inhibitor and Qianliehuichun capsule have definite therapeutic effect on chronic pelvic pain syndrome. The treatment of integrated traditional Chinese and western medicine is better than single treatment.