充血性心力衰竭患者细胞因子、血管紧张素II与射血分数的相关性研究

Correlation of cytokine and angiotensin II with left ventricular ejective fractions in patients with congestive heart failure

摘要目的:观察充血性心力衰竭(congestiveheartfailure,CHF)患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血浆血管紧张素II(angiotensinII,AngII)和左心室射血分数(leftventricularejectivefrac-tion,LVEF)的变化。方法:测定30例健康对照者和66例治疗前CHF患者TNF-α,TL-6和AngII浓度。并用彩色多普勒二维超声显像仪测定LVEF。结果:CHF组血清TNF-α,IL-6和血浆AngII水平明显高于健康对照组,差异有非常显著性意义(P<0.01)。血清TNF-α,IL-6水平与CHF的原发病无相关,而与LVEF呈负相关(r=-0.58,-0.62,P<0.01)。结论:CHF患者血清TNF-α,IL-6,AngII水平明显升高。且与LVEF呈负相关。

AIM:To observe the changes of serum tumor necrosis factor alpha(TNF α),serum interleukin 6(IL 6),angiotensin II(Ang II) and left ventricular ejective fraction(LVEF) in patients with congestive heart failure(CHF). METHODS:Serum concentrations of TNF α,IL 6 and Ang II were determined in normal controls(n=30) and patients with CHF(n=66) before treatment,and the LVEF was also estimated by using color Doppler two demensional echocardiography. RESULTS:Serum levels of TNF α,IL 6 and Ang II in the CHF group were significantly higher than those in the normal control group(P< 0.01).The serum levels of TNF αand IL 6 were not related with primary disease of CHF,but negatively related with LVEF(r=-0.58,-0.62,P< 0.01). CONCLUSION:The serum levels of TNF α,IL 6 and Ang II in patients with CHF are significantly increased,and negatively related with LVEF.