狼疮性肾炎95例临床分析

Clinical Analysis of 96 Cases of Lupus Nephritis

本文回顾性分析我院1966～1990年收治的134例系统性红斑狼疮(SLE)患者。其中狼疮性肾炎(LN)95例(占70.9％),以慢性肾炎型最多(占66.3％)。C_3水平降低和抗ds—DNA抗体效价升高与LN有密切关系,指出从临床表现、蛋白尿、管型和辅以免疫学的检查一般可确诊;治疗目前仍以激素为首选,用强的松30～60mg/d,6～8周35例,好转29例(82.9％),疗效较好,用强的松四周后疗效不满意者,加用免疫抑制剂,78.3％仍获缓解。死亡16例,病死率16.8％,半数以上死于尿毒症。

Ths clinical features of 134 cases suffering from systemic lupus erythremtosus (SLE) wrer analyzed. 95 cases of them were lupus nephritis (LN),in which 66.3％ of total LN were proved to be chronic nephritis type. It was showed that increased serum antibody of anti—DS — DNA. According to the clinical features, the presence of proteinuria and cast with supplementtary assays immunologically, a difinite diagnosis of LN can be make without the renipuncture biopsy. Hormone was still the first choice for LN treatment. If resistance to prednison commence after 4 weeks treatment, immunosuppressive drugs combined with hormone must be recommended. 16 cases died (16. 8％), and over half of them died in uremia.