西双版纳疟疾患者RESA抗体的初步调查

PRELIMINARY OBSERVATION ON ANTIBODY TO RESA IN MALARIA PATIENTS IN XISHUANGBAINA

用RESA—IFA试验对云南省西双版纳州恶性疟患者血样41份,恶性和间日疟原虫混合感染患者血样12份及间日疟患者血样38份进行RESA抗体检测。恶性疟患者阳性者9例,阳性率为22.0％(9/41);混合感染者阳性1例,阳性率为8.3％(1/12);间日疟患者全部阴性。RESA抗体阳性的患者IFA试验的GMRT为1552.1,阴性患者为741.8,差异非常显著。RESA抗体阳性患者平均原虫密度为5042个原虫/μl血,阴性患者为25398个原虫/μl血。表明恶性疟患者血清中的RESA抗体与临床免疫有一定关系。

Antibody to RESA of plasmodium falciparum from malaria patients in Xishuangbaina were tested by RE-SA-IFA. The positive rate of the antibody to RESA in falciparum malaria patients was 22. 0% (9/ 41), 8. 3% (1/12) in mixed falciparum and virax infections, and negative in 38 vivax patients. The GMRT of serum titer from patients with positive anti-RESA antibody and from those with negative results by IFA was 1552.1 and 741. 8 respectively (with significant difference statistically). The parasite densities in patients with anti-RESA antibody were lower in comparing with those patients with no anti-RESA antibody. These findings indicated that there was a parallel relationship between ami-RESA antibody liters and the acquisition of clinical immunity in malaria patients.