血吸虫病患者血清透明质酸检测的临床意义

A STUDY ON SERUM HYALURONATE LEVEL ON SCHISTOSOMIASIS PATIENTS AND ITS CLINICAL SIGNIFICANCE

本文应用放射分析法测定112例血吸虫病患者血清透明质酸(SHA)水平。晚期血吸虫病患者为469±512μg/l,慢性血吸虫病组为202±184μg/l,正常对照组为63±40μg/l。表明SHA是一项较好反映肝纤维化及其程度的临床生化指标,对病情判断、预后估价和药物疗效观察均具有一定的实用价值。

It has been known that hyaluronate (HA) was mainly taken up and degraded by the en-dothelial cells of liver sinusoids (LEC). Using the RIA, the level of serum HA (SHA) was measured in 112 patients with late and chronic stage schistosomiasis. The level of SHA was strikingly increased in late and chronic stage schistosomiasis (469 ± 512ug/l: 202±184ug/l). Elevated concentration of SHA could result from impaired LEC function, increased biosynthesis and portacaval shunting. It is suggested that the serum HA leval reflects both active fibrosis and hepatic failure, and may be a valuable clinical test of liver disease.