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大剂量白蛋白治疗对重症缺氧缺血性脑病新生儿神经行为评分及发育商的影响 被引量:1

Effect of large dose of human albumin therapy on neonatal behavioral neurological assessment score and development quotients in neonates with severe hypoxic ischemic encephalopathy
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摘要 目的:研究静脉应用大剂量白蛋白对重症新生儿缺氧缺血性脑病(hypoxicischemicencephalopathy,HIE)的疗效。方法:选择重症HIE患儿76例,分为2组:大剂量白蛋白治疗组48例,静脉滴注人血白蛋白2g/(kg·d),连续3~5d;常规治疗(对照)组28例,给予常规治疗。在日龄7,14,25~30d连续检查3次新生儿神经行为(neonatalbehavioralneurologicalassessment,NBNA)评分;3,6个月时用《儿心0~4岁精神发育量表》测定发育商。结果:大剂量白蛋白可显著性提高重度HIE新生儿NBNA评分(白蛋白组:25.33±3.19~35.91±3.08;常规组:26.01±3.47~32.11±3.20),差异有显著性意义(t=2.90~2.98,P<0.01);亦升高3,6个月时发育商(白蛋白组:94.01±10.81,93.10±9.07;常规组:80.01±12.33,84.91±10.19),差异有显著性意义(t=2.49,1.84,P<0.01)。结论:静脉滴注大剂量人血白蛋白可明显改善重度HIE新生儿的神经行为与及发育商。 AIM:To study the effect of venous drip of large dose of human albumin in neonates with severe hypoxic ischemic encephalopathy(HIE) METHODS:Seventy six severe HIE infants were divided into two groups:albuman treated group (n=48),receiving venous drip of 2 g/kg per day human albumin for 3-5 days successively,and control group(n=28),receiving routine treatment.The neonatal behavioral neurological assessment(NBNA) score was evaluated for 3 times continuously on day 7,14 and on days 25-30,respectively.Furthermore,the development quotient was assessed by 0-4 years old children psychological and mental development scale at 3,6 months. RESULTS:Large dose of human albumin could improve the NBNA scores (25.33±3.19 -35.91±3.08),significantly different from those in the control group(26.01±3.47 -32.11±3.20)(t=2.90-2.98,P< 0.01),The development quotient was also improved in the albuman treated group(94.01±10.81,93.10±9.07)at 3 and 6months,significantly different from that in the control group(80.01±12.33,84.91±10.19)(t=2.49,1.84,P< 0.01). CONCLUSION:Venous drip of large dose of human albumin can obviously improve the neuroethology and development quotient in neonates with severe HIE.
出处 《中国临床康复》 CSCD 2004年第18期3576-3577,共2页 Chinese Journal of Clinical Rehabilitation
基金 中山市科委基金资助项目(2001A063)~~
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