ICP—AES联合氢化法同时检测冠心病人血清30种元素临床研究

SIMULATAREOUS ASSAY OF 30'ELEMENTS IN CHD PATIENTS BY ICPAES NEBULIZATION-HYDRIDE GENERATION METHOD

本文报告55例冠心病人和55例健康人血清24种微量元素、6种宏量元素研究情况。这些元素采用ICP—AES联合氢化法同时检测。用国家标准物——人发(GBW—2143)、牛血清(GBW-09131)检验本法的准确性和控制检测质量。结果揭示:冠心病人血清元素变化与检索文献报道不大一致。①锌高,急性心肌梗塞 (以下简称AMI)明显降低。铜变化不明显。影响铜/锌比值是锌。②硒、硫均低,AMI最低。③铝高,AMI最高。④锶、硅也低。⑤与动脉硬化可能有关的钼、铬、钒、钴、锰、钙和镁等元素变化不明显;文献尚未提到与冠心病发病有关的硫低,AMI更低。迄今,健康人血清铍、硼及冠心病人血清硫、硅、砷、铝、锑、汞、铍、硼的检出值,尚未见报道,本文也提供了数据。

The reaserch of 24 trace elements and 6 maximum elements in 55 patients serum with Coronary Heart Disease (CHD) and in 55 healthy controls was reported in this article. These elements were measured by ICP-AES Ncbulization-Hyderide Generation method simulatareously. Accuracy of the method and quality control had been performed according to China Certified Reference Material (GBW-2143 and GBW-09131). The results showed: Change of the elements content in CHD serum comparing with the results reported has some difference. 1. Zinc content increases, but it drops in acute myocardial in farction (AMI). Copper content dosent change significantly Zinc effects the rate of Cu/Zn. 2. Selenium and Sulphur cuts down and is lowest in AMI. 3. Lead is higher, highest in AMI. 4. Strontium and Silicon are also lower. 5. Co-halt, Manganese, Molyb denum, Chromium, Vanadium, Calcium and Magnesium, arent difference significantly it wont reported that Sulphur in CHD is down and Lowest in AMI. So far the content of Beryllium, Boron in normal personts serum and Sulphur, Silicon, Arsenic, Aluminum, Antimony, Mercury, Beryllium, Boron in CHD havent Previously reported we affort the date of these elements.