左旋多巴治疗消化性溃疡初步探讨

Preliminary Study of Treating Peptic Ulcer with L-dopa

国外大量观察和研究发现消化性溃疡与体内多巴胺缺乏密切相关。由此,作者对103例消化性溃疡患者用L—dopa和Cimetidine进行了双盲对照研究,旨在了解L—dopa的抗溃疡作用,开拓消化性溃疡药物治疗的新途径。其中L—dopa组54例,完全随机分为三组,分别给予L—dopa 0.25 Bid,0.25qid,0.5 tid;对照组49例,给予口服Cimetidine0.2 tid,夜晚睡前加服0.4。疗程均为4周。结果表明,L—dopa对消化性溃疡腹痛的缓解率为90.8％,而抗溃疡作用则是剂量依赖性的,口服0.25 qid组和0.5 tid组溃疡愈合率与Cimetidine组溃疡愈合率差异无显著性(P>0.05),且无明显副作用。对L—dopa的抗溃疡作用机理进行了讨论。因此,作者认为L—dopa不失为一种有效、廉价、副作用小的抗溃疡药物,使用剂量以0.25qid为宜。

A large number of observes at abroad have founded that formation of peptic ulcer closdly associated with deficiency of dopamine in human boay. Accordingly, author performed a double-blind control study to 103 cases of peptic ulcer using L-dopa and cimetidine, among them, L-dopa group had 50 cases, they were subdivided as 3 groups, L-dopa 0.25 bid, 0. 25 qid and 0.5 tid were given by orally respectively. 49 cases in control group used cimitidine (0.2 tid and 0.4 qn) for 4 weeks. The results showed: abdominal pain remittent rate was 90.8% after using L-dopa with fewer side effcts, and its anti-ulcer action was dose-dependent. Ulcer-healing rate in two groups (0.25 qid and 0.5 tid) compared with that in cimitidine group, there was no significant difference (P>0.05). This paper discusses the macanisms of L-dopa on patients with PU, therefore, author consider that L-dopa is an efficient, cheaper anti-ulcer agent with fewer side effects, and dosage of 0.25 qid is better.