小鼠腹腔巨噬细胞C_3b受体

STUDIES ON C_3b RECEPTORS OF PERITONEAL MACROPHAGES IN MICE

用酵母补体花环试验检测小鼠腹腔M_φ的C_3b受体,结果看到不同品种小鼠腹腔M_φ的YC花环率不同,杂种昆明小鼠明显高于纯种BALB/c及C_(57)BL/6小鼠。不同年龄小鼠M_φ的YC花环率不同,青年小鼠明显高于老年小鼠。用糖元或黄芪给小鼠腹腔注射后,M_φYC花环率及吞噬率均比对照组明显升高,用免疫抑制剂氢化可的松注射后,M_φ的YC花环率及吞噬率均比对照组明显降低,以上结果表明M_φ的C_3b受体与M_φ的功能有密切关系。

C_3b receptors on the surface of mouse peritoneal macrophages have been investigated. The experimental results are as follows: ①The YC rosette percentage of macrophages from a hybrid species of Kunming mouse was higher than that of macrophages from inbred species of mice, BALB/c and C_(57)BL/6; ②The percentage of YC rosette of macrophages from younger animals was higher than that of macrophages from aged ones; ③The YC rosette percentage of macrophages activated by i. p. injection of glycogen or astragalus was increased significantly, while that of macrophages treated with hydrocortisone was decreased. It is suggested that the activity of C_3b receptors on the surface of macrophages might be closely related to the function of macrophages.