早期非胰岛素依赖型糖尿病患者肾小球滤过率(附39例病例分析)

CHARACTERISTICS OF GFR IN PATIENTS WITH EARLY STAGE NIDDM(REPORT OF 39 CASES)

观察39例在2a 内由糖耐量低减转为糖尿病的早期非胰岛素依赖型(NIDDM)糖尿病患者及24例正常人的肾小球滤过率(GFR),结果表明,早期 NIDDM 病例中血压正常者 GFR 较正常人高,伴有高血压者 GFR 较正常人低;舒张压与 GFR 呈显著负相关关系,高血糖使 GFR 升高,高血压使 GFR 降低,高血压对 GFR 的影响较其它因素更突出。

GFR was studied in 24 normal subjects as control and 39 patients with early stage N1D- DM turned from impaired glucose tolerance within 2 years.The results showed that GFR in early stage NIDDM patients without hypertension was elevated and in those with hypertension was low- ered significantly than that in normal subjects.There was a negative correlation between diastolic blood pressure and GFR in NIDDM patients.GFR was enhanced by hyperglycemia,and was re- duced by hypertension.