COPD病人血液流变学与血气变化的关系

Relationship between hemorreology and arterial blood gas changes in patients with chronic obstructure pulmonary disease (COPD)

74例急性发作期患者,同期行血气分析和血液流变学8项指标测定,并将COPD患者分为血气正常组和血气异常组与正常人组比较,同时根据PO_2和PCO_2情况将血气异常组分为A、B组进行对比分析,结果显示:血球压积随着PO_2下降及PCO_2上升而增加,而与PO_2下降关系更密切;全血比粘度(低切变速率)、全血还原比粘度和血浆比粘度与血球区积呈正相关(P<0.01),而血沉与血球压积则呈负相关(P<0.01),并随PO_2下降及PCO_2上升,其差异性更显著。作者认为,在治疗COPD时,应注意监测血气和血液流变学的变化。

In 74 patients with COPD,we analysed arterial blood gas and meanwhile checked and measured hemorrheology.The results showed that hematocrit increased with the decrease of PO2and with the increase of PCO2:blood viscosity ( low shear stress rate)and plasma viscosity correlated positively with hematocrit (P< 0.01 ),while the erythrocyte sedimentation rate correlated negatively with hematocrit (P< 0.01),and these differences were more notable when PO2decreased and PCO2increased . It suggested that the changes in blood gas and hemorrheology should be monitored during the treatment of COPD patients.