局部脑缺血—再灌注大鼠的主动和被动回避行为障碍

DISTURBANCE OF ACTIVE AND PASSIVE AVOIDANCE RESPONSE IN RATS WITH FOCAL CEREBRAL ISCHEMIA-REPERFUSION

用避暗法和穿梭箱法,研究了局部脑缺血一再灌注雄性 Wistar 大鼠的学习行为。脑缺血一再灌注损伤后3天,被动回避反应已有障碍,缺血一再灌注组的测验日潜伏期较假手术组显著缩短(P<0.05)。术后7天,缺血一再灌注组的回避反应少于假手术组,在训练的第1天尤其如此(P<0.01)。这些结果表明局部脑缺血一再灌注大鼠的两种学习行为均有损害,并提示这种大鼠可用作血管性痴呆的动物模型。

Learning behavior in adult male Wistar rats exposed to focal cerebral ischemia-reperfu sion were investigated in one-trial passive avoidance(step-through)and two-way active avoidance tasks (shuttle-box).Three days after cerebral ischemia-reperfusion,learning in one-trial passive avoidance tasks was disturbed.The latency on the test day in ischemia-reperfused rats was shorter than that in sham-operated rats(P<0. 05).Seven days after operation,the focal cerebral ischemia-reperfused rats were also impaired acquisition of two-way active avoidance response.The number of avoidance re- sponses in ischemia-reperfused rats were fewer than that in sham-operated ones,especially like that on the first day in training(P<0.01).Theses results suggest that rats with focal cerebral isehemia-reper- fusion are impaired in two different types of learning tasks,and may be useful as an animal model for the vascular type of dementia.