慢性肾衰贫血患者尿促红细胞生成素浓度的变化及意义

SIGNIFICANCE AND CHANGES OF THE URINE ERYTHROPOIETIN IN PATIENTS WITH CHRONIC RENAL FAILURE ANEMIA

本实验采用“胎鼠肝细胞体外培养法”测定了40例正常人和75例不同原因贫血患者尿促红细胞生成素(EPO)浓度。结果显示:①慢性肾衰(CRF)贫血组尿 EPO 浓度明显低于正常组(P<0.001);②血液病贫血组尿 EPO 浓度明显高于正常组(P<0.001),且再生障碍性、溶血性贫血患者与其它原因血液病贫血患者比较有显著意义(P<0.002和 P<0.05);③心肺疾患组尿 EPO 浓度也明显高于正常组(P<0.001)。我们认为尿 EPO 浓度测定在诊断 CRF 贫血和鉴别不同原因疾病贫血方面有一定参考意义。

By use of the fetal mouse liver cell culture technique in vivo,urine erythropoietin (EPO)was measured in 75 patients with different causes of anemia and 40 healthy subjects.The re suits showed:comparing to the urine EPO in healthy subjects,chronic renal failure(CRF)anemia group was extremely Iower(P<0. 001).and the patients suffering from anemia of blood diseases and cardiopuimonary diseases groups were much highcr(P<0. 001).Besides these,there was a marked dif- tercnee between aplastic anemia &.hemolytic anemia and other kinds of blood diseases(P<0.002,P <0.05).We concluded that the determination of urine EPO might take important role in diagnosing CRF anemia and distinguishing different kinds of anemia.