糖尿病患者10种游离脂肪酸的变化

The changes of 10 kinds of free fatty acid in diabetes patients

本文对92例糖尿病患者血清中的游离脂肪酸(FFA)进行了检测。观察了正常对照组和糖尿病组的 FFA 值及糖尿病组治疗前后的 FFA 变化.结果显示糠尿病组 C16∶0,C18∶0较对照组高(P<0.01),而C18∶1,C18∶2,C18∶3较对照组低(P<0.01).在经过有效的降糖治疗后,C16∶0,C18∶0下降明显(P<0.01);C18∶1,C18∶2,C20∶4明显升高(P<0.01).对糖尿病患者上述 FFA 异常的机理作了讨论,认为对糖尿病患者的 FFA 异常应予以重视,有效的降糖治疗,纠正糖尿病患者脂肪酸的组成异常对防治心血管系统并发症具有重要意义。

10 kinds of freefatty acid of serum were investigated in 92 patients with diabetes mellitus and 30 controls.The results showed that the proportions of palmitic acid(16:0) and stearic acid (18: 0) increased in the patients.On the other hand the proportions of oleic acid (18:1),linoleic acid (18:2) and Gamma linolenic acid (18:3) decreased.The proportions of palmitic and stearic acid decreased and the proportions of oleic,linoleic and Gamma lmolenic acid increased after hypoglycemic treatment.The data emphasized the need to pay attention to the changes of fatty acid and to correct them.