抗子宫内膜抗体对子宫内膜异位症的诊断意义

Evaluation of antiendometrial antibody in patients with endometriosis

采用纯化的人子宫内膜抗原以间接 ELISA 法检测经手术或腹腔镜证实的子宫内膜异位症(EMT)患者62例、单纯子宫肌腺病者8例及正常对照组30例的血标本,结果发现 EMT 组抗子宫内膜抗体(EMAb)阳性率为58.06%,EMT 合并不育者阳性率为72.22%,均明显高于对照组6.67%及子宫肌腺病组12.5%,并且发现 EMT 组中 EMAb 的阳性率随其分期的升高而下降,Ⅳ期 EMT 之阳性率已与对照组无差异。认为 EMAb 的检测不失为一种对 EMT 患者无损伤的、经济方便的辅助诊断方法,尤其对轻度 EMT 患者更具有价值.

Sera from 62 cases with endometriosis,8 cases with ade- nomyosis and 30 controls were studied by Enzyme-linked immunosorb- ent assay.The diagnosis of all cases and the controls were proved by laparoscopy or laparotomy.The results showed that the positive rate of antiendometrial antibody was 58.06% in endometriosis,72.22% in endo- metriosis with infertility,12.5% in adenomyosis and 6.67% in the con- trols.The positive rate in endometriosis and endometriosis with infer- tility were higher than that in adenomyosis and the controls(P<0.01). Negative correlation between the degree of endometriosis and positive rate of antiendometrial antibody could be determined.These findings suggest that determination of antiendometrial antibody is a possibility to develope a noninvasive and convenient test for the presence of endo- metriosis,especially mild endometriosis.