冬虫夏草对氨基糖甙肾毒性损伤的保护作用

Amelioration of aminoglycoside nephrotoxicity by Cordyceps Sinensis

本文前瞻性地观察了冬虫夏草对氨基糖甙(AG)类肾毒性的影响。按随机双盲将54例患者分为冬虫夏草治疗组和安慰剂组。两组同时接受庆大霉素6mg·kg^(-1)/d(18～32岁)或丁胺卡那霉素0.4g/d(55～73岁)注射,连续6天。动态观察尿NAG酶和β_2微球蛋白排泄的结果表明,冬虫夏草治疗组肾毒性损伤要轻于单用AG的对照组。冬虫夏草对临床AG肾毒性损伤具有良好的保护作用。

54 patients, matched in sex, age, were randomly divided into two groups. Each group received aminoglycosides, In addition group A was administered Cordyceps Sinensis and group B was given placebo simultaneously in a double-blind manner. The results demonstrated that group A developed less prominent nephrotoxicity compared with group B as evidenced by less urinary NAGase and β_2-microglobulin in group A than those in group B. These results suggested that Cordyceps Sinensis exerted a protective effect on aminoglycoside nephrotoxicity.