尿素氮动力学模型在血液透析中的应用

Application of a urea kinetic model to hemodialysis schedule

应用单室尿素氮动力学模型的方法,对30例慢性维持性血液透析患者进行质量平衡分析,着重研究了透析时效和两次透析间的间隔时数,即透析频率(次/周)这两个参数。透析时效根据Daugirdas法计算,透析间隔时效根据由动力学模型推导出来的计算式进行计算。将二者结果用于临床,根据临床康复状态进行判别,并经统计学检验分析,P>0.05,与临床情况无差异,此法的最大特点是根据个体差异定量预计欲达充分透析所需的时数和每周所需的透析次数,体现了个体化治疗方案,为确保透析质量提供了依提。

The purpose of this paper is to determine the desired dialysis length (T) and interval length (θ) for an individual patient. 30 patients on MHD were investigated, undergoing hemodialysis from 5 to 79 months and with blood flow rate of 150 to 250ml/min. The dialysis length was calculated by Daugirdas Method. The interval length was calculated by formulas derived from single-pool urea kinetic model. The calculation of T and θ determined a dialysis schedule, compared with clinical restored status. The results showed no significant difference by statistical test. This provides a sound theoretical basis for the individualized dialysis schedule.