新生儿败血症合并新生儿硬肿症血浆肿瘤坏死因子-α水平的变化

PLASMA TUMOR NECROSIS FACTOR ALPHA LEVELS IN NEONATES WITH SCLEREDEMA NEONATORUM ASSOCIATED WITH SEVERE SEPSIS

用L929细胞生物学活性法测定了10例新生儿败血症合并新生儿硬肿症患者的血浆肿瘤坏死因子-α(TNFα)水平,其值为788.0±685.61u/ml,显著高于新生儿败血症患者、单纯寒冷因素所致新生儿硬肿症患者及正常新生儿,死亡组的TNFα水平又较存活组显著增高。提示TNFα水平的增高与严重败血症所致新生儿硬肿症的发病和预后有关。

Because of the possible involvement of shock in almost all scleredema neonatorum associated with severe sepsis, we investigated plasma levels of tumor necrosis factor alpha (TNF-alpha) in these patients. Significantly higher TNF-alpha leves were found in the septic patients with scleredema with a mean of 788.0+/-686.61u/ml compared with those without sclere- dema and the patients with scleredema caused by cold injury, Moreover, TNF-alpha levels were remarkedly higher in the patients who died than those who survived. These data, for the first time in the world, provided the evidence that TNF-alpha might play a key role in the pathogenesis of scleredema neonatorum associated with severe sepsis.