23株金黄色葡萄球菌L型返祖前后药物敏感试验的对比研究

THE COMPARABLE STUDY ON 23 COLONIES OF L-PHASE S. AUREUS BEFORE AND AFTER ATAVISM

从23例新生儿金黄色葡萄球菌型败血症病儿分离所得株金葡萄L型,在返祖前后用纸片扩散法作药物敏感试验的对比。4种作用于细胞壁的青霉素,在细菌返祖前后除新青Ⅱ56.5％耐药外,其他3种80％以上耐药,且返祖前后无明显差异。先锋霉素V同样作用于细胞壁,耐药者较少.临床疗效亦尚好,说明不同类型作用于细胞壁的抗生素,对L型菌的耐药性不同。对抑制细胞质内蛋白质合成,以及干扰细胞内蛋白质合成的抗生素,返祖前后除洁霉素外耐药者均较少,因此临床可选用此类药物治疗。

23 Colonies of L-phese S, aureus were seperated from 23 newborns with septicemia of L-phase S, aureus, and comparision of the drug sensitivity was made by the paper diffusion method before and after atavism. The results showed that 3 of 4 types of penicillin acting on the bacterial wall were drug-resistant over 80% and the fourth, (i.e,oxacillin) was drug- resistant by 56.5% before and after atavism, cefazolinum natricum, also acting on the bacterial wall, was less drug-resistant with better effect in clinic, suggesting that different types of biotics with the same acting mec- hanism were drug resisttant differently. The bictics, which could inhibit and interfer with the protein synthsis in the bacterial plasma were seldom drug resistant with the exception of Lincomycin with or without the atavi- sm,Thus, these biotics may be selected to use clinically. However, it is emphasized that if one type of biotics is obviously effective in clinic, it is not necessary to change it.