血清铜/锌比值在肝癌鉴别诊断中的应用

Clinical Application if Serum Copper—zinc Ratio in Differential Diagnosis of Hepatic Cancer

本文选择89年9月至90年1月住院病人39例,进行分组;另设对照组17例;采用国产WYX—402型原子吸收分光光度计(ASS)分别测得血清铜、锌及铜/锌比值。结果表明肝硬化组与正常组比较血清铜无显著差异(P>0.05),血清锌降低(P<0.05),铜/锌比值显著增高(P<0.001)。肝硬化并发肝癌组与肝硬化组比较,血清铜显著增高(P<0.001),血清锌无显著差异(P>0.05),铜/锌比值显著增高(P<0.001)。继发性肝癌组与原发性肝癌组比较,血清铜、锌及铜/锌比值均无显著性差异(P 值分别大于0.1;0.2)。研究表明,血清铜/锌比值 AFP测定有互补作用。

Cirrhosis and primary hepatic cancer are two closely related diseases and about fifty tro ninety percent of the primary hepatic cancers are associated with cirrhosis,so cirrhosis is regarded as precondition of the primary hepatic cancer.But it is difficlt to judge the early malignant stage in cirrgosis,especially in the patients of the AFP negative.The methods of judging malignancy from cirrhosis have attracteda great deal of attention.In the differential diagmosis of cirrhosis andhepatic tumor,we own that the crossed cases of the critical copper—zincvalue were fifty percent of serum copper and copper—zinc radio had a supplement action to AFP,so it can be used in the differdtial diagnosis of primary hepatic tumor as a simple,effective method.