隆化县深山区自然人群银屑病流行病学调查

EPIDEMIOLOGICAL INVESTIGATION OF PSORIA SIS IN MOUNTAINOUS AREAS

1987年调查了河北省隆化县两个地处深山区乡村的银屑病发病情况,其患病率为2.26％,家族患病率为18.52％,明显高于自然人群患病率,说明遗传因素在银屑病病因中起一定的作用。家谱调查提示本病不具备单基因遗传规律,且Ⅱ、Ⅲ级亲属患病率明显低于Ⅰ级亲属患病率,符合多基因遗传特点。除遗传因素外,环境等某些因素对本病的发生可能也起一定的作用。

An epidemiological investigation of psoriasis was made in two townships located in mountainous areas of Longhua county, Hebei provience. The prevalence in general population was 2.26‰. The prevalence in families with positive family history of psoriasis was 18.52‰; it was obviously higher than that in general population. The results show that genetic factor plays a definite role in the pathogenesis of psoriasis; but pedigrees analysis suggests that psoriasis does not possess the characteristics of typical monogenic genetic disease. The prevalence of psoriasis in second-and third-grade relatives of family members with psoriasis were far lower than that in first-grade relatives. The results correspond with polygenic genetic rule. Enviromental factors have a definite influence on pathogenesis besides genetic factor.