食管癌术前放疗的评价——附1012例分析

VALUE OF PREOPERATIVE RADIOTHERAPY OF ESOPHAGEAL CARCINOMA--Analysis of 1012 patients

选择1960年至1986年计划性术前放疗食管癌276例,与同期736例单纯手术者进行比较,术前放疗皆为40Gy/4周病例,间隔2～4周进行手术,由于术前放疗,术后病理分期综合组Ⅲ期减少,其余资料两组无统计差异。综合组与手术组5年生存率分别为29.7％(82/276)和19.2％(141/736);10年生存率分别为21.8％(50/229和15.0％(83/553),P<0.05.术后切残存、淋巴结转移率手术组皆高于综合组,P<0.01;病变位于中上段者5年生存率综合组高于手术组,P<0.05。

276 esophagcal cancer patients treated from 1960 to 1986 by planned preoperat-ive radiotherapy and surgery (combined group). 736 similar patients treated during the same interval by surgery alone served as control(surgcry grup). 40 Gy/4 wk was given which was followed by a 2-4 weeks rest before operation. The clinical data in these two groups were comparable except that there was less pathology stageⅢ patients in the combined group. The 5-year survival rates of the combined and surgery groups were 29.7% (82/276) and 19.2% (141/736). The respective 10-year survival rates were 21.8% (50/229) and 15.0% (8.3/55) (P<0.05). The frequency of positive stump and lymphnode metastasis were higher in the surgery group (P<0.01). The 5-year survival rates of lesions in the upper and mid-segments were also higher in the combined group (P<0.05).