鼻咽癌高剂量率近距离治疗的近期疗效

PRELIMINARY EXPERIENCE IN HDR BRACHYTHERAPY FOR 72 NASOPHARYNGEAL CARCINOMA (NPC) PATIENTS

1989年4月至1991年7月,72例鼻咽癌患者采用外照射加腔内放疗,其中根治性外照射后局部残存39例,复发6例,补量11例,计划性内外照射16例.腔内剂量参考点距施源器10～12mm,多数给予8Gy/次,1～3次,每周1次。局部控制在外照后局部残存组为100％,复发组为50％,总局控率93。3例发生软腭穿孔。

From April 1989 to July 1991, 72 patients with pathologically proven residual or recurrent NPC were treated by irradiation combined with MSH 192Ir brachytherapy. The brachytherapy was given: in 39 patients with residual disease at the primary site after radical irradiation, in 6 patients for recurrence after radical external radiation therapy, to 11 patients as a supplement to irradiation, and in the other 16 as a planned intracavitary managememt in combination with irradiation. The overall local control rate was 93.3%. For residual and recurrent diseases , the local control rates were 100% and 50%, respectively. In 3 patients, it was complicated by soft palate perforation. The authors believe that HDR brachytherapy is useful for residual or recurrent NPC following radical irradiation.