不同分割方法放疗鼻咽癌的前瞻性随机分组研究

DIFFERENT FRACTIONATION TECHNIQUES IN THE RADIOTHERAPY FOR NASOPHARYNGEAL CARCINOMA (NPC)——a randomized trial on 120 patients

1987～1988年对120例鼻咽癌随机分组(40例/组)治疗,A组连续照射60～70Gy/30～35f/6～7W,B组超分割61.6～70.4Gy/56～64f/6～7W(上午120cGy,间隔6小时,下午100cGy)C组60～70Gy/30～35f/9～11W分段放疗,一半剂量时休息3～4周。3年生存率A组67.5％,B组87.5％,C组67.5％。3年死亡于局部复发者A、B组各2例,C组3例,死于远地转移A组8例,B组2例,C组6例。远期后遗症B组最少。

From July 1987 to July 1988,120 NPC patients were randomly divided into three groups:Group A,conventional fractionation(60-70Gy/30-35 F,6-7 wk),Group B,hyperfractionation(am 1. 2 Gy,4-6 hr. later,1 Gy,to a total of 61. 6-70. 4 Gy/56-64 F,6-7 wk),and Group C,split course(30-34 Gy/15-17 F,3-3. 5wk,3-4 week rest,and 30-36 Gy/15-18F,3-3. 5wk). The results showed that the tumor control rates in 3 months were:Group A-77. 5% ,Group B-95. 0%,and Group C-90. 0%. The 3-year survival rates were:Group A-67. 0%, Group B-87. 5% and Group C-67. 0%. The acute radiation reaction in Group B was more severe than the other two groups.