尼群地平对扩张型心肌病心力衰竭的急性血流动力学作用

ACUTE HEMODYNAMIC EFFECTS OF NITRENDIPINE ON HEART FAILURE CAUSED BY DILATED CARDIOMYOPATHY

应用Swan-Gazn导管测定9例扩张型心肌病心力衰竭患者1次口服尼群地平20～40mg前后的急性血流动力学参数变化。结果:用药后30min血流动力学指标明显改善,用药后1～2h、RAP、PCWP、SVR、TPR及PAR进一步降低,而CO、CT、SVI及SWI显著增加,与用药前相比差异显著(P<0.01)。而用药前后HR无改变。表明尼群地平对扩张型心肌病心力衰竭具有良好的血流动力学作用。

In the present study, the acute hemodynamic effects of asingle dose of oral nitrendipine (20-40mg) was observed by using Swan-Ganz catheter in 9 dilated cardiomyopathy patients with chronic heart failure. The results showed that the hemodynamic coefficient changed significantly 30 minutes after administration of the drug At subsequent 1 to 2 hours, RAP, PCWP, SVR, TPR and PAR further decreased, and CO, CI, SVI and SWI increased significantly (P<0.01), but HR did not change (P>0.05) . This indicates that nitrendipine has useful hemodynamic effects on heart failure caused by dilated cardiomyopathy.